What is CBG (Cannabigerol), and how can it help?
You are probably used to CBD and THC, but did you know that other special cannabinoids can be found in the cannabis plant? A good example is CBG, which has been gaining popularity within the last few years.
CBG is an abbreviation for Cannabigerol, a cannabinoid derived from the cannabis plant. There are currently more than 120 cannabinoids. CBG was first isolated in 1964, and since then, numerous tests and studies have been conducted to find its chemical make-up and its numerous therapeutic benefits.
CBG as a minor cannabinoid
It is referred to as a minor cannabinoid due to its low-level availability in the cannabis plant (less than 1%). CBG is referred to as the 'mother of cannabinoids' since three major cannabinoids - THC, CBD, and CBC, can be directly linked to CBG.
CBGA (the acid that corresponds with CBG) is the forerunner to three cannabinoid acids, namely CBCA (cannabichromenic acid), CBDA (cannabidiolic acid), and THCA (tetrahydrocannabinolic acid). The enzymes present in the cannabis plant help convert CBGA into these acids. Through decarboxylation, the remaining CBGA is then converted to CBG, and the other acids are turned into CBC, CBD, and THC, respectively.
How does CBG help?
Cannabigerol has been linked to numerous medical benefits making it one of the most sought-after products in the cannabinoid market. It has shown great strides in the treatment and management of the following diseases/conditions.
Glaucoma is a painful eye condition characterized by intraocular pressure that may cause severe optic nerve damage leading to blindness. CBG does reduce pressure and restore normal sight. While THC can also do the same, CBG offers a non-intoxicating option for patients.
Depression and anxiety
Serotonin and GABA are inhibitory neurotransmitters that facilitate good moods, calmness, relaxation, and positivity. Low levels of these compounds lead to anxiety and depression. CBG helps regulate the uptake of GABA and Serotonin to ensure that they stay at an optimum level.
Millions of people suffer from one or more mental conditions, which is among the leading causes of suicides worldwide. CBG offers a working solution.
Patients suffering from conditions such as inflammatory bowel disease can use CBG to relieve pain and minimize inflammation.
A study was done, and patients with IBD were treated with CBG. The results indicated that CBG was vital in managing abdominal and joint pain, poor appetite and cramping.
A recent study showed that CBG induces hunger without any psychotropic effects on the consumer. The discovery could be used as a method to help people suffering from low appetite and cachexia.
Eradicating bacterial infections
Methicillin-resistant Staphylococcus Aureus (MRSA) is a drug-resistant bacterium that has remained stubborn for years until CBG was introduced. CBG kills bioforms formed by the bacteria and inhibits the production of new ones making CBG an effective antibiotic.
Fighting cancer cell growth
CBG possesses strong anti-cancer properties and can effectively inhibit the abnormal growth of cancer cells. According to numerous studies conducted, CBG is effective in destroying cells in patients with varying cancer forms.
Managing Huntington's disease
The disease is fatal and currently has no cure. The patient's mental and physical abilities deteriorate as time goes by, and its life expectancy is around 20years from the time symptoms start to show.
Don't be so sad! CBG is a neuroprotective compound that has shown great strides in treating neurodegenerative conditions like Huntington's disease by normalizing the abnormal cells that cause the brain to degenerate. CBG helps to protect the brain and promote the growth of new healthy cells.
Though not a cure, it is hope and helps in slowing the progression of the disease.
Similarities between CBG and CBD
From the information above, you can gather that both CBG and CBD;
Are derived from the cannabis plant
Do not have intoxicating properties on the user, unlike their counterpart, THC.
- Have numerous medical benefits on the user
Differences between CBG and CBD
Despite the similarities, these two compounds have several differences, which include;
CBD's affinity for cannabinoid receptors is quite low; hence it works indirectly with the endocannabinoid system. On the other hand, CBG interacts directly with the CB1 and CB2 receptors of the brain.
CBG is rare to find since it is found in small amounts in the cannabis plant (less than 1%). As a result, it takes a lot of biomass to produce a significant amount of CBG. CBD, however, is in plenty, with some cannabis strains recording a 20% CBD content.
CBG and CBD have varying molecular structures. The structure is determined by the number of hydrogen atoms making up a compound and how they are arranged. The molecular structure difference means that they interact differently with the human body and possess varying solubility properties.
CBG can convert into other cannabinoids. CBGA is converted to THCA, CBDA, and CBCA. These acids are then turned to THC, CBD, and CBC and the remaining CBGA to CBG during the decarboxylation process.
- CBG is present during the early stages of the growth of the hemp plant. CBD is formed when the hemp plants start to mature.